Recent Advances in Asymmetric Functionalization of Olefins Induced by Chiral Hypervalent Iodine Reagents

The functionalization of olefins induced by chiral hypervalent iodine reagents is a basic method for obtaining enantiomerically enriched molecules and biologically active natural products. It one the new promising fields in asymmetric synthesis. Throughout past 20 years development this area, on hand, stereoselective functionalizations alkenes such as disulfonyloxylation, diacetoxylation, dihalogenation, diamination, hydroxylation-sulfonyloxylation halogenation-alkylation carbonylation have been successfully achieved with through intermolecular reactions, which various functionalized products were enantioselectively obtained. On other many hetero-cyclic compounds γ-butyrolactones, chromans, isochromans, oxazolidinones, piperidines, pyrrolidines aziridines can be synthesized intramolecular oxidative lactonization, etherification, amidation, arylation provide efficient methods synthesis heterocyclic compounds. In addition, reactions mediated afford target excellent yield enantioselectivity. Thus, methodology has also used total their applications are reviewed.